Monkey anti-PEG IgG ELISA Test

Monkey anti-PEG IgG ELISA Test

Attachment of polyethylene glycol (PEG) chains to therapeutic biologic agents, a process referred to as PEGylation, prolongs the circulating half-life of the modified protein by slowing proteolytic degradation and by masking it from the immune system. However, it has been reported that repeated injections of PEGylated proteins can induce anti-PEG antibodies that increase the rate of clearance and decrease drug efficacy (accelerated blood clearance, or ABC phenomenon). In our own studies, we find that a single injection of PEGylated protein, induced high anti-PEG IgG titers (refer to the “Sample Preparation” section.) To aid research in this important area, we have developed a monkey anti-PEG IgG ELISA kit.

Monkey anti-PEG IgG ELISA Test